Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062932 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTMEN1KMT2ARAB9A | |
| SCHEMBL8692811 | 0.75 | KDM4E (0.43) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18703764 | 0.75 | NPC1 (0.47) | ALDH1A1MAPTRAB9AMAPK1LMNA | |
| SCHEMBL4538724 | 0.74 | MAPT (0.43) | SMN1; SMN2ALDH1A1MAPTRECQLRAB9A | |
| SCHEMBL7404303 | 0.74 | MAPT (0.46) | SMN1; SMN2ALDH1A1MAPTRECQLMAPK1 | |
| SCHEMBL12298619 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL21962708 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1MAPK1LMNAL3MBTL1 | |
| SCHEMBL12590746 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL372414 | 0.73 | SELE (0.38) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31729297 | 0.72 | SSTR4 (0.45) | SMN1; SMN2ALDH1A1MAPTRECQLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615847-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | Merck Sharp & Dohme LLC (US) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024103010-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2024-05-16 | — | — | WO | disclosed |