Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30961867 | 0.78 | PDE4B (0.42) | PIK3CD | |
| SCHEMBL30961743 | 0.76 | NR1H2 (0.44) | ESR2PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL30961796 | 0.75 | QDPR (0.43) | PLK1 | |
| SCHEMBL24688876 | 0.70 | KRAS (0.35) | — | |
| SCHEMBL30961798 | 0.70 | RORA (0.34) | — | |
| SCHEMBL30961847 | 0.70 | HPGD (0.38) | — | |
| SCHEMBL21311005 | 0.69 | NR1H2 (0.38) | DGAT2ESR2PIK3CACNR2GPR119 | |
| SCHEMBL29197658 | 0.69 | ESR2 (0.55) | DGAT2ESR2PIK3CDGPR119GRIA1 | |
| SCHEMBL21425206 | 0.68 | MAPT (0.50) | ESR2GPR119 | |
| SCHEMBL31749917 | 0.68 | CDK9 (0.39) | ESR2PIK3CDGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4633739-A1 | COMPOUNDS AND COMPOSITION FOR TARGETING TP53-Y220C MUTANTS | Flare Therapeutics, Inc. (US) | 2025-10-22 | — | — | EP | disclosed |
| WO-2024129715-A1 | COMPOUNDS AND COMPOSITION FOR TARGETING TP53-Y220C MUTANTS | FLARE THERAPEUTICS INC. (US) | 2024-06-20 | — | — | WO | disclosed |