Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30961923 | 0.75 | POLB (0.46) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL1588164 | 0.75 | POLB (0.50) | TIPARPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5757671 | 0.72 | CHRNB2 (0.53) | — | |
| SCHEMBL5759446 | 0.71 | ALDH1A1 (0.47) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL4812347 | 0.71 | CHRNB2 (0.51) | — | |
| SCHEMBL31574277 | 0.71 | SYK (0.41) | KDM4E | |
| SCHEMBL21521967 | 0.68 | TIPARP (1.00) | TIPARPALDH1A1POLB | |
| SCHEMBL21521232 | 0.68 | TIPARP (0.68) | TIPARPALDH1A1HPGD | |
| SCHEMBL30694880 | 0.68 | MAPT (0.43) | ALDH1A1MAPTKMT2AKDM4ERAB9A | |
| SCHEMBL30694876 | 0.68 | CHRNB4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149933-B1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | HOFFMANN LA ROCHE (CH) | 2024-06-12 | — | — | EP | claimed |