Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 5/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107560 | 1.00 | MAPT (0.39) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL16654904 | 0.91 | MERTK (0.44) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL137478 | 0.91 | TDP1 (0.38) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL2411379 | 0.89 | PIN1 (0.39) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL16059862 | 0.89 | MAPT (0.38) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL26608049 | 0.82 | HSPB1 (0.53) | MAPTALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL16386609 | 0.76 | LMNA (0.38) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL106458 | 0.76 | MET (0.37) | MAPTALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL25254710 | 0.75 | TSHR (0.47) | MAPTALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL14975595 | 0.75 | GCK (0.47) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024085695-A1 | NOVEL ALTIRATINIB DERIVATIVE, MANUFACTURING METHOD THEREFOR, AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION, ALLEVIATION, OR TREATMENT OF SKIN PIGMENTATION | 재단법인 아산사회복지재단 | 2024-04-25 | — | — | WO | disclosed |