Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25045587 | 1.00 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL30107670 | 0.89 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL15850502 | 0.89 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL30665751 | 0.88 | BCHE (0.63) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL27323740 | 0.88 | BCHE (0.63) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL30965470 | 0.83 | GRIN2B (0.39) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL25045588 | 0.83 | GRIN2B (0.39) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL30965473 | 0.82 | ALOX5 (0.53) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL25045580 | 0.82 | ALOX5 (0.53) | NPC1RAB9ASMN1; SMN2KDRFGFR3 | |
| SCHEMBL10555895 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | SQSTM1, MCL1, HSPA2 | NPC1 1454/4885RAB9A 701/4885SMN1; SMN2 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.