Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078427 | 0.88 | LRRK2 (0.48) | ATRRIPK1PIK3CAMTORPIK3CG | |
| SCHEMBL3084428 | 0.88 | RIPK1 (0.48) | ATRRIPK1HDAC4PIK3CAMTOR | |
| SCHEMBL14041306 | 0.88 | RIPK1 (0.48) | ATRRIPK1HDAC4PIK3CAMTOR | |
| SCHEMBL3090291 | 0.80 | TGFBR1 (0.44) | HPGDPARP1ALDH1A1 | |
| SCHEMBL3089198 | 0.79 | ALOX5 (0.52) | AURKBCDK1CDK2CDK9PARP1 | |
| SCHEMBL4908920 | 0.78 | RIPK1 (0.55) | ATRRIPK1HDAC4PIK3CAMTOR | |
| SCHEMBL17645897 | 0.78 | RIPK1 (0.55) | ATRRIPK1HDAC4PIK3CAMTOR | |
| SCHEMBL4748880 | 0.76 | RIPK1 (0.48) | ATRRIPK1HDAC4PIK3CAMTOR | |
| SCHEMBL14041305 | 0.76 | RIPK1 (0.48) | ATRRIPK1HDAC4PIK3CAMTOR | |
| SCHEMBL4936228 | 0.73 | GSK3A (0.60) | RIPK1SMN1; SMN2HPGDJAK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | claimed |
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | ASTRAZENECA AB (SE) | 2010-09-16 | — | — | US | disclosed |
| WO-2008121063-A1 | NEW IMIDAZO[ 4,5-B]PYRIDINE-7-CARBOXAMIDES 704 | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234593-A1 | Imidazo[4,5-B]Pyridine-7-Carboxamides 704 | HDAC4, HDAC7, BRD4 | ATR 3849/4885RIPK1 4004/4885HDAC4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.