Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31125221 | 0.86 | CYP3A4 (0.42) | CYP3A4TSHRPTPN11PGK1ALDH1A1 | |
| SCHEMBL31357853 | 0.79 | PTPN11 (0.41) | CYP3A4PTPN11PGK1IKBKB | |
| SCHEMBL31125223 | 0.77 | KDM4E (0.46) | CYP3A4PTPN11PGK1ALDH1A1MAPT | |
| SCHEMBL287497 | 0.75 | PTPN11 (0.41) | CYP3A4PTPN11PGK1ALDH1A1MAPT | |
| SCHEMBL38658837 | 0.75 | CYP3A4 (0.50) | CYP3A4TSHRALDH1A1HTTCA1 | |
| SCHEMBL31125232 | 0.75 | GAA (0.42) | TSHRPTPN11ALDH1A1POLBHPGD | |
| SCHEMBL29490274 | 0.73 | KCNH2 (0.43) | CYP3A4TSHRPTPN11PGK1LMNA | |
| SCHEMBL21246857 | 0.73 | KCNH2 (0.43) | CYP3A4TSHRPTPN11PGK1LMNA | |
| SCHEMBL30966829 | 0.72 | PTPN11 (0.43) | CYP3A4PTPN11PGK1 | |
| SCHEMBL29236439 | 0.72 | MEN1 (0.40) | PTPN11PGK1MEN1KMT2AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852145-A | GSPT1 degradation agent and application thereof | 南京圣和药业股份有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118184639-A | GSPT1 degradation agent and application thereof | 南京圣和药业股份有限公司 | 2024-06-14 | — | — | CN | disclosed |