Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 known ✓ | P09237 | 1/20 | 0.97 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.97 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.98 |
| ▸ | USP2 | O75604 | 6/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.97 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.97 |
| ▸ | MMP2 | P08253 | 1/20 | 0.97 |
| ▸ | MMP3 | P08254 | 1/20 | 0.97 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | RECQL | P46063 | 8/20 | 0.89 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.89 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.89 |
| ▸ | HPGD | P15428 | 7/20 | 0.69 |
| ▸ | MEN1 | O00255 | 7/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19270298 | 0.99 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| SCHEMBL30708253 | 0.99 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| SCHEMBL21793722 | 0.99 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| SCHEMBL29399816 | 0.99 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| SCHEMBL29388088 | 0.99 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| SCHEMBL29800447 | 0.99 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| Hydrochloric Acid SCHEMBL29763226 | 0.98 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| Water SCHEMBL29358570 | 0.98 | MMP2 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| Hydrochloric Acid SCHEMBL30533349 | 0.98 | TDP1 (1.00) | TDP1USP2HSD17B10HIF1ATSHR | |
| Alcohol SCHEMBL29362779 | 0.94 | KDM4E (1.00) | TDP1USP2HSD17B10HIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4661860-A1 | TREATMENT OF NEURODEGENERATIVE DISORDERS WITH DOXYCYCLINE ALONE OR IN COMBINATION WITH LEVODOPA | Biohaven Therapeutics Ltd. (VG) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024167878-A1 | TREATMENT OF NEURODEGENERATIVE DISORDERS WITH DOXYCYCLINE ALONE OR IN COMBINATION WITH LEVODOPA | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-08-15 | — | — | WO | disclosed |