Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL571078 | 0.93 | ALDH1A1 (0.50) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL28033613 | 0.92 | ALDH1A1 (0.48) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15993929 | 0.89 | ALDH1A1 (0.46) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL119893 | 0.85 | CA4 (0.59) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL692736 | 0.85 | CA4 (0.59) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL20456925 | 0.85 | CA4 (0.59) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL275858 | 0.85 | CA4 (0.59) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15993893 | 0.85 | ALDH1A1 (0.42) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15323413 | 0.84 | CA4 (0.53) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL3998443 | 0.84 | CA4 (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853299-B1 | ARYL SCISSION INHIBITION IN ARYL-FUNCTIONALIZED POLYSILOXANE | DOW SILICONES CORP (US) | 2025-08-20 | — | — | EP | disclosed |
| US-12024612-B2 | Aryl scission inhibition in aryl-functionalized polysiloxane | DOW SILICONES CORPORATION (US) | 2024-07-02 | — | — | US | disclosed |