Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28033613 | 0.98 | ALDH1A1 (0.48) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL15993929 | 0.95 | ALDH1A1 (0.46) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL30979602 | 0.93 | MEN1 (0.41) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL20456923 | 0.91 | ALDH1A1 (0.60) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL2345400 | 0.91 | ALDH1A1 (0.60) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL15993893 | 0.91 | ALDH1A1 (0.42) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL2345397 | 0.90 | CA4 (0.52) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL5324670 | 0.90 | ALDH1A1 (0.58) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL15323421 | 0.90 | ALDH1A1 (0.58) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Citric Acid SCHEMBL22443181 | 0.90 | ALDH1A1 (0.58) | ALDH1A1LMNAMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 686 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12551441-B2 | Water soluble silicon-containing granulate | BIO MINERALS NV (BE) | 2026-02-17 | — | — | US | claimed |
| EP-4614632-A1 | DEEP EUTECTIC SOLVENTS-BASED ELECTROLYTE COMPOSITIONS | BeFC (FR) | 2025-09-10 | — | — | EP | claimed |
| WO-2025088479-A1 | PROCESS FOR RECYCLING LITHIUM BATTERIES | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2025-05-01 | — | — | WO | claimed |
| US-20250073175-A1 | Intra-Dosage Form Coatings and Applications Thereof | BALCHEM CORPORATION | 2025-03-06 | — | — | US | claimed |
| CN-119529137-A | Natural rubber solidification system, natural rubber, and preparation method and application thereof | 中国化工集团曙光橡胶工业研究设计院有限公司 | 2025-02-28 | — | — | CN | claimed |
| EP-4489731-A2 | INTRA-DOSAGE FORM COATINGS AND APPLICATIONS THEREOF | Balchem Corporation (US) | 2025-01-15 | — | — | EP | claimed |
| CN-119285754-A | Method for extracting collagen from fish skin | 浙江工商大学 | 2025-01-10 | — | — | CN | claimed |
| US-12171224-B2 | Choline salt and ammonium-free adjuvants for water conditioning and agricultural formulations | SPECIALTY OPERATIONS FRANCE (FR) | 2024-12-24 | — | — | US | claimed |
| CN-119157034-A | Planting method for preventing and controlling rice blast | 黑龙江省农业科学院佳木斯分院 | 2024-12-20 | — | — | CN | claimed |
| US-20240408130-A1 | Combination of Silicon and Magnesium for the Prevention and Treatment of Muscle Cramps | BIO MINERALS N.V. (BE) | 2024-12-12 | — | — | US | claimed |
| WO-1992013468-A1 | NOVEL CHOLINE-CONTAINING COMPOSITIONS AS SALT SUBSTITUTES AND ENHANCERS AND METHOD OF PREPARATION | INTERNEURON PHARMACEUTICALS INCORPORATED (US) | 1992-08-20 | — | — | WO | claimed |
| EP-0389667-A2 | Use of lecithin to restore olfaction and taste | PHARMACAPS, INC. (US) | 1990-10-03 | — | — | EP | claimed |
| US-4948589-A | CHOLINE COATED WITH HYDROPHOBIC FILM FOR DELAYED DISSOLVING | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1990-08-14 | — | — | US | claimed |
| US-4917685-A | POROUS MEMBRANE CONFINING ACTIVE MATERIALS AND STABILIZERS | INTERNATIONAL MINERALS & CHEM. CORP. | 1990-04-17 | — | — | US | claimed |
| US-4816568-A | AMINO ACIDS, POLYPEPTIDES, CHOLINE SALTS | INTERNATIONAL MINERALS & CHEMICAL CORP. (US) | 1989-03-28 | — | — | US | claimed |
| EP-0303746-A1 | Stabilization of growth promoting hormones | Mallinckrodt Group Inc. (US) | 1989-02-22 | — | — | EP | claimed |
| EP-0019054-B1 | NUTRIENT MEDIUM AND ITS USE IN TESTING ANTIMICROBIAL AGENTS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-05-05 | — | — | EP | claimed |
| US-4309205-A | APPLYING AQUEOUS SOLUTION OF CHOLINE SALT TO IMPROVE QUANTITY AND QUALITY OF FLOWERS OR FRUIT | THE STATE OF ISRAEL MINISTRY OF AGRICULTURE (IL) | 1982-01-05 | — | — | US | claimed |
| US-4275154-A | Nutrient medium | HOFFMANN-LA ROCHE INC. (US) | 1981-06-23 | — | — | US | claimed |
| EP-0019054-A1 | Nutrient medium and its use in testing antimicrobial agents | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12171224-B2 | Choline salt and ammonium-free adjuvants for water conditioning and agricultural formulations | ACHE, PHOSPHO1, CHAT | MEN1 2734/4885ALDH1A1 4587/4885LMNA 3927/4885 |
| US-12551441-B2 | Water soluble silicon-containing granulate | SI, GIPR, VIP | MEN1 2488/4885ALDH1A1 3151/4885LMNA 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.