SCHEMBL30983856

SCHEMBL30983856

CC(C)(C)OC(=O)N1CCN(CCOc2ccc(-c3nc4c(OC5(C)CC5)ncnc4n3Cc3cc(Cl)ccn3)c(Cl)c2)CC1

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 2/20 0.41
▸ CNR2 P34972 2/20 0.41
▸ GPR4 P46093 1/20 0.38
▸ PIK3CD O00329 14/20 0.36
▸ EPHX2 P34913 1/20 0.35
▸ SQOR Q9Y6N5 1/20 0.35
▸ RET P07949 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30983841 0.92 CNR1 (0.41) CNR1CNR2GPR4PIK3CDEPHX2
SCHEMBL30983836 0.92 CNR1 (0.41) CNR1CNR2GPR4PIK3CDEPHX2
SCHEMBL30983781 0.92 CNR1 (0.39) CNR1CNR2GPR4PIK3CD
SCHEMBL30983874 0.91 GPR4 (0.38) CNR1CNR2GPR4EPHX2SQOR
SCHEMBL30983875 0.91 CNR1 (0.41) CNR1CNR2GPR4PIK3CDEPHX2
SCHEMBL30983802 0.90 CNR1 (0.43) CNR1CNR2GPR4PIK3CDEPHX2
SCHEMBL30983946 0.90 CNR1 (0.44) CNR1CNR2GPR4PIK3CDEPHX2
SCHEMBL30983965 0.87 EPHX2 (0.39) CNR1CNR2GPR4EPHX2SQOR
SCHEMBL30983893 0.87 CNR1 (0.42) CNR1CNR2GPR4PIK3CDEPHX2
SCHEMBL31268916 0.87 DRD2 (0.34) CNR1PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
EP-4630410-A1 POLQ INHIBITORS Astrazeneca AB (SE) 2025-10-15 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
WO-2024121753-A1 POLQ INHIBITORS ASTRAZENECA AB (SE) 2024-06-13 — — WO disclosed
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