Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK1 | P53355 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983894 | 0.81 | DAPK1 (0.65) | DAPK1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL30983919 | 0.81 | DAPK1 (0.47) | DAPK1HPGDCYP19A1MEN1HTT | |
| SCHEMBL30983811 | 0.77 | DAPK1 (0.62) | DAPK1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL31269114 | 0.75 | DAPK1 (0.60) | DAPK1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL30983852 | 0.72 | MEN1 (0.42) | DAPK1HPGDFLT4KDRMEN1 | |
| SCHEMBL3880941 | 0.69 | CNR1 (0.46) | — | |
| SCHEMBL21076782 | 0.66 | TLR7 (0.42) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL31388163 | 0.64 | GAA (0.46) | HPGDTSHRALDH1A1SMN1; SMN2 | |
| 9-Benzyl-6-Methoxy-9H-Purine SCHEMBL28939425 | 0.63 | HPGD (0.77) | DAPK1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL11018617 | 0.62 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |