Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990047 | 0.88 | MET (0.51) | ROCK2ROCK1PTGER4PTGER2MET | |
| SCHEMBL30989879 | 0.87 | LMNA (0.55) | ROCK2ROCK1MAPK1PTGER4PTGER2 | |
| SCHEMBL30989948 | 0.84 | TP53 (0.55) | ROCK2ROCK1MAPK1PTGER4PTGER2 | |
| SCHEMBL30989952 | 0.84 | TP53 (0.55) | ROCK2ROCK1MAPK1PTGER4PTGER2 | |
| SCHEMBL30989843 | 0.82 | PTGER4 (0.56) | MAPK1PTGER4PTGER2POLBMEN1 | |
| SCHEMBL30989895 | 0.82 | KCNA5 (0.52) | ROCK2ROCK1PTGER4PTGER2MET | |
| SCHEMBL30989931 | 0.81 | PTGER4 (0.55) | ROCK2ROCK1PTGER4PTGER2MET | |
| SCHEMBL30990007 | 0.79 | PTGER4 (0.53) | ROCK2ROCK1PTGER4PTGER2MET | |
| SCHEMBL30989786 | 0.78 | RXFP1 (0.45) | MAPK1PTGER4PTGER2RIPK1POLB | |
| SCHEMBL30989984 | 0.77 | PTGER4 (0.42) | PTGER4PTGER2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |