Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30990007 | 0.95 | PTGER4 (0.53) | PTGER4PTGER2MAPTMETROCK2 | |
| SCHEMBL30989952 | 0.89 | TP53 (0.55) | PTGER4PTGER2ROCK2ROCK1PDE10A | |
| SCHEMBL30989948 | 0.89 | TP53 (0.55) | PTGER4PTGER2ROCK2ROCK1PDE10A | |
| SCHEMBL30989843 | 0.84 | PTGER4 (0.56) | PTGER4PTGER2POLBTP53HSP90AA1 | |
| SCHEMBL30989895 | 0.81 | KCNA5 (0.52) | PTGER4PTGER2METROCK2ROCK1 | |
| SCHEMBL30989888 | 0.81 | ROCK2 (0.53) | PTGER4PTGER2METROCK2ROCK1 | |
| SCHEMBL30989879 | 0.80 | LMNA (0.55) | PTGER4PTGER2MAPTROCK2ROCK1 | |
| SCHEMBL30989984 | 0.79 | PTGER4 (0.42) | PTGER4PTGER2MAPT | |
| SCHEMBL30990047 | 0.78 | MET (0.51) | PTGER4PTGER2MAPTMETROCK2 | |
| SCHEMBL25449962 | 0.77 | ALDH1A1 (0.46) | PTGER4PTGER2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |