Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989852 | 1.00 | GPBAR1 (0.36) | GPBAR1PTGDR2TRPM8JAK2JAK3 | |
| SCHEMBL30990045 | 0.91 | GPR6 (0.38) | GPBAR1PTGDR2JAK2JAK3JAK1 | |
| SCHEMBL30989902 | 0.91 | GPR6 (0.38) | GPBAR1PTGDR2JAK2JAK3JAK1 | |
| SCHEMBL30989905 | 0.85 | KDM4C (0.40) | GPBAR1PTGDR2GPR6ADRA2APIK3C3 | |
| SCHEMBL30989941 | 0.85 | MAPK1 (0.43) | GPBAR1PTGDR2TRPM8PIK3C3KDM4C | |
| SCHEMBL30990023 | 0.85 | MAPK1 (0.43) | GPBAR1PTGDR2TRPM8PIK3C3KDM4C | |
| SCHEMBL30989764 | 0.81 | SCN9A (0.33) | GPR6 | |
| SCHEMBL30989933 | 0.81 | P2RX7 (0.42) | JAK2JAK3JAK1GPR6 | |
| SCHEMBL30989929 | 0.81 | P2RX7 (0.42) | JAK2JAK3JAK1GPR6 | |
| SCHEMBL30989894 | 0.78 | SPR (0.47) | GPBAR1TRPM8PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |