Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 9/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | EP300 | Q09472 | 3/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30993004 | 0.70 | CREBBP (0.45) | KMT2ACREBBPBRD4EP300TRIM24 | |
| SCHEMBL30993555 | 0.70 | CREBBP (0.42) | MEN1KMT2ACREBBPBRD4 | |
| SCHEMBL17185312 | 0.69 | APOBEC3A (0.61) | MEN1KMT2ACYP3A4CYP2C9NPC1 | |
| SCHEMBL30993379 | 0.69 | CREBBP (0.41) | KMT2ACREBBPBRD4EP300TRIM24 | |
| SCHEMBL5219361 | 0.68 | GAA (0.44) | MEN1KMT2AHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL31023088 | 0.67 | HSD17B10 (0.41) | MEN1KMT2AHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL30993826 | 0.67 | CREBBP (0.39) | KMT2ACREBBPBRD4EP300BRD3 | |
| SCHEMBL5220565 | 0.67 | CTSD (0.42) | MEN1KMT2AHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL5221504 | 0.67 | CTSD (0.51) | MEN1KMT2AHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL5216170 | 0.66 | HSD17B10 (0.41) | MEN1KMT2AHSD17B10CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024130095-A1 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-20 | — | — | WO | disclosed |