Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PRLHR | P49683 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GPR183 | P32249 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31018186 | 1.00 | TRPV1 (0.39) | TRPV1PTGDR2NPC1RAB9APRLHR | |
| SCHEMBL3099388 | 1.00 | TRPV1 (0.39) | TRPV1PTGDR2NPC1RAB9APRLHR | |
| SCHEMBL11997790 | 0.93 | PTGDR2 (0.37) | TRPV1PTGDR2NPC1RAB9APRLHR | |
| SCHEMBL13096371 | 0.92 | MAPT (0.40) | PTGDR2NPC1RAB9APRLHRMAPT | |
| SCHEMBL11997379 | 0.86 | HPGD (0.41) | TRPV1PTGDR2NPC1RAB9APRLHR | |
| SCHEMBL3102935 | 0.81 | TRPV1 (0.40) | TRPV1PTGDR2RAB9APRLHRMAPT | |
| SCHEMBL11997380 | 0.81 | KCNH2 (0.36) | MAPTHPGDGAAGPR183 | |
| SCHEMBL3102946 | 0.81 | TRPV1 (0.40) | TRPV1PTGDR2RAB9APRLHRMAPT | |
| SCHEMBL3101555 | 0.80 | MAPT (0.46) | NPC1RAB9AMAPTHPGDHTT | |
| SCHEMBL3101567 | 0.80 | MAPT (0.46) | NPC1RAB9AMAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112437771-B | Bronchodilating heteroatom-linked amides | 阿凯德制药公司 | 2024-06-18 | — | — | CN | disclosed |
| US-11680054-B2 | Bronchodilating hetero-linked amides | ARCEDE PHARMA AB (SE) | 2023-06-20 | — | — | US | disclosed |
| EP-3818055-B1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | RESPIRATORIUS AB PUBL (SE) | 2022-02-16 | — | — | EP | disclosed |
| US-20210139455-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | ARCEDE PHARMA AB (SE) | 2021-05-13 | — | — | US | disclosed |
| EP-3818055-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | Respiratorius AB (Publ) (SE) | 2021-05-12 | — | — | EP | disclosed |
| CN-112437771-A | Novel bronchodilator heteroatom-linked amides | 瑞思拜尔锐特略斯股份公司 | 2021-03-02 | — | — | CN | disclosed |
| WO-2020009653-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | RESPIRATORIUS AB (PUBL) (SE) | 2020-01-09 | — | — | WO | disclosed |
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| EP-2181095-B1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2012-08-22 | — | — | EP | disclosed |
| EP-2181095-B1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2012-08-22 | — | — | EP | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| WO-2009007420-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11680054-B2 | Bronchodilating hetero-linked amides | PTGIS, PTGIR, ADRB2 | TRPV1 249/4885PTGDR2 67/4885NPC1 3717/4885 |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | PTGIS, ADRB2, ADRB1 | TRPV1 537/4885PTGDR2 30/4885NPC1 1040/4885 |
| US-20210139455-A1 | NOVEL BRONCHODILATING HETERO-LINKED AMIDES | ADRB2, ADRB1, PTGIS | TRPV1 234/4885PTGDR2 80/4885NPC1 3518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.