Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ME2 | P23368 | 1/20 | 0.45 |
| ▸ | ME1 | P48163 | 1/20 | 0.45 |
| ▸ | ME3 | Q16798 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101555 | 1.00 | MAPT (0.46) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL13096376 | 0.90 | MAPT (0.59) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3101865 | 0.90 | MEN1 (0.52) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3101854 | 0.90 | MEN1 (0.52) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3100471 | 0.81 | PTGDR2 (0.48) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3100463 | 0.81 | PTGDR2 (0.48) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL31018186 | 0.80 | TRPV1 (0.39) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3099388 | 0.80 | TRPV1 (0.39) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3099369 | 0.80 | TRPV1 (0.39) | MAPTHPGDHTTLMNANPC1 | |
| SCHEMBL3259529 | 0.80 | MAPT (0.46) | MAPTHPGDHTTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318768-B2 | Bronchodilating alpha, beta-unsaturated isoquinoline amides | RESPIRATORIUS AB (SE) | 2012-11-27 | — | — | US | disclosed |
| EP-2181095-B1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2012-08-22 | — | — | EP | disclosed |
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | ARCEDE PHARMA AB (SE) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256101-A1 | NOVEL BRONCHODILATING ALPHA, BETA-UNSATURATED ISOQUINOLINE AMIDES | PTGIS, ADRB2, ADRB1 | MAPT 2764/4885HPGD 43/4885HTT 4454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.