SCHEMBL30995403

SCHEMBL30995403

COc1ccc(COc2c(F)cc(C(=O)NCC34CCC(c5nc(-c6ccnc(S(C)(=O)=O)n6)cs5)(CC3)CC4)c(F)c2F)cc1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.32
CSF1R P07333 1/20 0.32
EGFR P00533 1/20 0.31
CYP3A4 P08684 1/20 0.31
BRAF P15056 1/20 0.31
JAK3 P52333 1/20 0.31
MAPK10 P53779 1/20 0.31
KCNH2 Q12809 1/20 0.31
ERBB4 Q15303 1/20 0.31
CA2 P00918 2/20 0.31
CA4 P22748 2/20 0.31
P2RX7 Q99572 3/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
KAT8 Q9H7Z6 2/20 0.31
DPP4 P27487 1/20 0.31
ROCK2 O75116 1/20 0.30
ROCK1 Q13464 1/20 0.30
KLKB1 P03952 1/20 0.30
ADAM17 P78536 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29319434 1.00 SLC6A9 (0.32) SLC6A9CSF1REGFRCYP3A4BRAF
SCHEMBL29319440 0.89 CSF1R (0.32) CSF1RP2RX7MEN1KMT2ADPP4
SCHEMBL30995334 0.89 CSF1R (0.32) CSF1RP2RX7MEN1KMT2ADPP4
SCHEMBL30995409 0.83 ACHE (0.37)
SCHEMBL29319429 0.83 ACHE (0.37)
SCHEMBL27213785 0.76 P2RX7 (0.40) SLC6A9KCNH2P2RX7KLKB1P2RY12
SCHEMBL27391240 0.76 P2RX7 (0.40) SLC6A9KCNH2P2RX7KLKB1P2RY12
SCHEMBL30995282 0.75 P2RX7 (0.40) SLC6A9KCNH2P2RX7P2RY12
SCHEMBL29318715 0.75 P2RX7 (0.40) SLC6A9KCNH2P2RX7P2RY12
SCHEMBL29317993 0.75 P2RX7 (0.39) SLC6A9KCNH2P2RX7MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4634169-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF Pfizer Inc. (US) 2025-10-22 EP disclosed
WO-2024127297-A1 3-FLUORO-4-HYDROXYBENZMIDE-CONTAINING INHIBITORS AND/OR DEGRADERS AND USES THEREOF PFIZER INC. (US) 2024-06-20 WO disclosed