Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | GCKR | Q14397 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24738932 | 0.87 | GAA (0.45) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL30828305 | 0.87 | RAB9A (0.55) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL282866 | 0.84 | DEGS1 (0.51) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL31706891 | 0.83 | GAA (0.44) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL23582651 | 0.82 | GSK3B (0.43) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL10044267 | 0.82 | SYK (0.40) | GAAPOLBRAB9ANPC1GSK3B | |
| SCHEMBL23582524 | 0.80 | HDAC1 (0.41) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL31357577 | 0.80 | HDAC1 (0.41) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL31705856 | 0.79 | GAA (0.55) | GAAPOLBRAB9APTGS1NPC1 | |
| SCHEMBL4599319 | 0.79 | PDK1 (0.49) | NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |