Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23502328 | 0.88 | SMN1; SMN2 (0.64) | PDK1PDK2PDK3PDK4NAMPT | |
| SCHEMBL1138925 | 0.85 | EPHX2 (0.59) | NAMPTCYP17A1ALDH1A1MAPTEPHX2 | |
| SCHEMBL28298376 | 0.83 | NAMPT (0.52) | PDK1PDK2PDK3PDK4NAMPT | |
| SCHEMBL13055402 | 0.83 | CYP17A1 (0.59) | NAMPTSMN1; SMN2CYP17A1PSMB8ALDH1A1 | |
| SCHEMBL18275167 | 0.82 | ALDH1A1 (0.50) | PDK1PDK2PDK3PDK4NAMPT | |
| SCHEMBL12387210 | 0.82 | PDK1 (0.55) | PDK1PDK2PDK3PDK4NAMPT | |
| SCHEMBL10176299 | 0.82 | SMN1; SMN2 (0.54) | PDK1PDK2PDK3PDK4NAMPT | |
| SCHEMBL19853212 | 0.82 | NAMPT (0.54) | NAMPTSMN1; SMN2CYP17A1PSMB8CA12 | |
| SCHEMBL19180948 | 0.80 | PDK1 (0.54) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL21047664 | 0.80 | SMN1; SMN2 (0.72) | PDK1PDK2PDK3PDK4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076376-B2 | Aniline sulfonamide derivatives and their uses | AMGEN INC. | 2011-12-13 | — | — | US | disclosed |
| US-8076376-B2 | Aniline sulfonamide derivatives and their uses | AMGEN INC. | 2011-12-13 | — | — | US | disclosed |
| US-8076376-B2 | Aniline sulfonamide derivatives and their uses | AMGEN INC. | 2011-12-13 | — | — | US | disclosed |
| EP-1907357-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | Amgen Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007013929-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2007-02-01 | — | — | WO | disclosed |
| US-20070021502-A1 | Aniline sulfonamide derivatives and their uses | AMGEN INC. | 2007-01-25 | — | — | US | disclosed |
| US-20070021502-A1 | Aniline sulfonamide derivatives and their uses | AMGEN INC. | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021502-A1 | Aniline sulfonamide derivatives and their uses | ARSA, SULT2A1, SULT1A1 | PDK1 967/4885PDK2 354/4885PDK3 584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.