Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Donepezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.89 |
| ▸ | BCHE | P06276 | 7/20 | 0.89 |
| ▸ | FAAH | O00519 | 1/20 | 0.89 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.89 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.89 |
| ▸ | PDE5A | O76074 | 1/20 | 0.89 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.89 |
| ▸ | APP | P05067 | 1/20 | 0.89 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.89 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.89 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.89 |
| ▸ | DRD4 | P21917 | 1/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.89 |
| ▸ | MAOB | P27338 | 1/20 | 0.89 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Donepezil SCHEMBL3118020 | 0.94 | BCHE (0.89) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3110131 | 0.94 | BCHE (0.92) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3112749 | 0.94 | BCHE (0.92) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL14674406 | 0.94 | BCHE (0.96) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL18815528 | 0.94 | BCHE (0.96) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL12043710 | 0.94 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL8265876 | 0.94 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3516 | 0.94 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3851203 | 0.94 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL2149 | 0.94 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130296283-A1 | POLYMORPHS OF DONEPEZIL SALTS, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2013-11-07 | — | — | US | disclosed |
| US-8501779-B2 | Polymorphs of donepezil salts, preparation methods and uses thereof | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2013-08-06 | — | — | US | disclosed |
| EP-2204364-B1 | POLYMORPHS OF DONEPEZIL SALTS, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2013-03-20 | — | — | EP | disclosed |
| US-20100311793-A1 | POLYMORPHS OF DONEPEZIL SALTS, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO-TECH CO., LTD (CN) | 2010-12-09 | — | — | US | disclosed |
| EP-2204364-A1 | POLYMORPHS OF DONEPEZIL SALTS, PREPARATION METHODS AND USES THEREOF | Tianjin Hemey Bio-Tech Co., Ltd. (CN) | 2010-07-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296283-A1 | POLYMORPHS OF DONEPEZIL SALTS, PREPARATION METHODS AND USES THEREOF | ME1, SDHA, GLS | ACHE 386/4885BCHE 377/4885FAAH 3000/4885 |
| US-20100311793-A1 | POLYMORPHS OF DONEPEZIL SALTS, PREPARATION METHODS AND USES THEREOF | ME1, SDHA, GLS | ACHE 386/4885BCHE 377/4885FAAH 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.