Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1540028 | 0.88 | ALDH1A1 (0.49) | ALDH1A1CYP1A2HPGDMAPTKMT2A | |
| SCHEMBL2444986 | 0.86 | ALDH1A1 (0.50) | ALDH1A1CYP1A2HPGDFBP1MAPT | |
| SCHEMBL2082176 | 0.85 | ALDH1A1 (0.67) | ALDH1A1CYP1A2HPGDFBP1MAPT | |
| SCHEMBL741937 | 0.85 | HSD17B10 (0.49) | ALDH1A1CYP1A2HPGDMAPTKMT2A | |
| SCHEMBL2444646 | 0.83 | L3MBTL1 (0.46) | ALDH1A1CYP1A2HPGDMAPTKMT2A | |
| SCHEMBL5221270 | 0.81 | ALDH1A1 (0.44) | ALDH1A1CYP1A2HPGDFBP1MAPT | |
| SCHEMBL31661300 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CYP1A2HPGDFBP1MAPT | |
| SCHEMBL1552396 | 0.77 | ALDH1A1 (0.69) | ALDH1A1CYP1A2HPGDFBP1MAPT | |
| SCHEMBL2823884 | 0.76 | ALDH1A1 (0.63) | ALDH1A1CYP1A2HPGDFBP1MAPT | |
| SCHEMBL3095838 | 0.75 | FBP1 (0.66) | ALDH1A1CYP1A2HPGDFBP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632134-B | 2- (4-thiazolinone-2-imino) thiazole-5-carboxylic ester and preparation method and application thereof | 湖南大学 | 2020-01-03 | — | — | CN | disclosed |
| US-7795289-B2 | Use of acylaminothiazole derivatives as therapeutic agents | SANOFI-AVENTIS (FR) | 2010-09-14 | — | — | US | disclosed |
| US-20080051436-A1 | Use of Acylaminothiazole Derivatives as Therapeutic Agents | SANOFI-AVENTIS (FR) | 2008-02-28 | — | — | US | disclosed |
| US-7291636-B2 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-11-06 | — | — | US | disclosed |
| US-20050182104-A1 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051436-A1 | Use of Acylaminothiazole Derivatives as Therapeutic Agents | BACE1, BACE2, ATG4A | ALDH1A1 1460/4885CYP1A2 2175/4885HPGD 2538/4885 |
| US-20050182104-A1 | Acylaminothiazole derivatives, preparation and therapeutic use thereof | BACE1, APP, BACE2 | ALDH1A1 1639/4885CYP1A2 2038/4885HPGD 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.