Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 2/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2366 | 0.84 | LTB4R2 (0.47) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL1911 | 0.83 | LTB4R2 (0.48) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL2291 | 0.82 | LTB4R2 (0.35) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2563 | 0.76 | ITGB1 (0.42) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL8484079 | 0.75 | LTB4R2 (0.40) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL2311 | 0.75 | ITGB1 (0.43) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL7270209 | 0.73 | LTB4R2 (0.45) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL2318 | 0.72 | ACHE (0.44) | ACHEOXTRAVPR1AITGB1ITGA4 | |
| SCHEMBL2922 | 0.72 | LTB4R2 (0.37) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL9430039 | 0.72 | LTB4R2 (0.50) | ACHEOXTRAVPR1AITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |