Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 8/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 8/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29178512 | 0.65 | PIM1 (0.38) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL28053689 | 0.65 | SIRT6 (0.43) | FLT3PIK3CA | |
| SCHEMBL31233456 | 0.64 | SIGMAR1 (0.33) | KCNJ6KCNJ5KCNJ3LMNA | |
| SCHEMBL29397706 | 0.64 | KCNJ6 (0.70) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL32663018 | 0.61 | BTK (0.36) | PIK3CA | |
| SCHEMBL29011046 | 0.61 | NEK7 (0.32) | — | |
| SCHEMBL29484498 | 0.61 | NEK7 (0.43) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL23905698 | 0.61 | PKMYT1 (0.37) | PIK3CA | |
| SCHEMBL1380340 | 0.60 | CCNC (0.34) | — | |
| SCHEMBL25286218 | 0.60 | KCNJ6 (0.72) | KCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240252473-A1 | Sulfoximines as inhibitors of NaV1.8 | GRUENENTHAL GMBH (DE) | 2024-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240252473-A1 | Sulfoximines as inhibitors of NaV1.8 | SCN8A, SCN10A, SCN7A | KCNJ6 89/4885KCNJ5 73/4885KCNJ3 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.