Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053688 | 0.76 | KMT2A (0.53) | SIRT6KMT2ABACE1KITFLT3 | |
| SCHEMBL29178512 | 0.74 | PIM1 (0.38) | KMT2ATSHRPDK2 | |
| SCHEMBL32663018 | 0.73 | BTK (0.36) | BACE1PIK3CA | |
| SCHEMBL14755714 | 0.72 | SIRT6 (0.45) | SIRT6KMT2AADORA3TSHRMC4R | |
| SCHEMBL2635320 | 0.72 | SIRT6 (0.73) | SIRT6KMT2AADORA3TSHRMC4R | |
| SCHEMBL30908333 | 0.71 | P4HA1 (0.46) | — | |
| SCHEMBL29990008 | 0.71 | P4HA1 (0.46) | — | |
| SCHEMBL25324096 | 0.70 | TRPA1 (0.33) | — | |
| SCHEMBL31365783 | 0.70 | TRPA1 (0.33) | — | |
| SCHEMBL30567607 | 0.70 | GABRP (0.40) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103797010-B | As the azetidinyl phenyl of JAK inhibitor, pyridyl or pyrazinyl carboxamides derivatives | INCYTE HOLDINGS CORP. (US) | 2016-02-24 | — | — | CN | disclosed |