Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.48 |
| ▸ | KAT7 | O95251 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.48 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.48 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3100518 | 1.00 | NPC1 (0.51) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3096420 | 0.93 | GPR27 (0.48) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3093127 | 0.93 | GPR27 (0.48) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3079467 | 0.92 | F2 (0.43) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3092060 | 0.92 | KAT6A (0.47) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3093284 | 0.90 | KAT6A (0.49) | NPC1RAB9AKAT6AMAPTSMN1; SMN2 | |
| SCHEMBL3093039 | 0.90 | MEN1 (0.50) | NPC1RAB9AKAT6AMAPTTP53 | |
| SCHEMBL3093304 | 0.90 | LARS1 (0.42) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3086182 | 0.90 | LARS1 (0.42) | NPC1RAB9AKAT6AKAT7CYP3A4 | |
| SCHEMBL3096503 | 0.90 | LARS1 (0.45) | NPC1KAT6AMAPTLARS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20100228026-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100228026-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | REN, AGTR2, AGTR1 | NPC1 3306/4885RAB9A 826/4885KAT6A 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.