Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379700 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| SCHEMBL29411650 | 0.75 | NPC1 (0.68) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| SCHEMBL14624343 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| 2-Picolinic Acid SCHEMBL11829119 | 0.73 | LMNA (0.67) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| SCHEMBL28092518 | 0.73 | NPC1 (0.81) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| SCHEMBL21833012 | 0.72 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AGAAKDM4E | |
| SCHEMBL2807153 | 0.72 | RAB9A (1.00) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| SCHEMBL1147702 | 0.71 | KDM4E (0.73) | SMN1; SMN2NPC1RAB9APKMKDM4E | |
| SCHEMBL15968945 | 0.71 | CTNNB1 (0.54) | SMN1; SMN2NPC1RAB9ACYP1A2PKM | |
| SCHEMBL11829134 | 0.71 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ACYP1A2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4655401-A1 | TREATMENT OF STROKE WITH 1,4-ALPHA-GLUCAN-BRANCHING ENZYME (GBE1) INHIBITORS | Regeneron Pharmaceuticals, Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024158888-A1 | TREATMENT OF STROKE WITH 1,4-ALPHA-GLUCAN-BRANCHING ENZYME (GBE1) INHIBITORS | REGENERON PHARMACEUTICALS, INC. (US) | 2024-08-02 | — | — | WO | disclosed |
| US-20240247267-A1 | Treatment Of Stroke With 1,4-Alpha-Glucan-Branching Enzyme (GBE1) Inhibitors | REGENERON PHARMA (US) | 2024-07-25 | — | — | US | disclosed |