Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039307 | 1.00 | NT5E (0.38) | NT5EKDM4ETAS2R14CTSSALDH1A1 | |
| SCHEMBL28928751 | 0.79 | MEN1 (0.35) | KDM4EGPR35GAAHPGD | |
| SCHEMBL855006 | 0.79 | NT5E (0.47) | NT5EKDM4EALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL21614639 | 0.77 | HSP90AA1 (0.40) | KDM4ETAS2R14CTSSALDH1A1LMNA | |
| SCHEMBL29882555 | 0.77 | HSP90AA1 (0.40) | KDM4ETAS2R14CTSSALDH1A1LMNA | |
| SCHEMBL23580667 | 0.77 | HSP90AA1 (0.40) | KDM4ETAS2R14CTSSALDH1A1LMNA | |
| SCHEMBL25991641 | 0.74 | TAS2R14 (0.39) | KDM4ETAS2R14CTSSALDH1A1LMNA | |
| SCHEMBL24027397 | 0.74 | CTSS (0.36) | KDM4ETAS2R14CTSSALDH1A1LMNA | |
| SCHEMBL20399842 | 0.73 | KDM4E (0.41) | NT5EKDM4ETAS2R14CTSSALDH1A1 | |
| SCHEMBL24133935 | 0.73 | KDM4E (0.36) | KDM4ETAS2R14CTSSLMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100050-A1 | PYRIDINE-2-YL-CARBOXYLIC ACID AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |
| US-20100227887-A1 | PYRIDINE-2-YL CARBOXYLIC ACID AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227887-A1 | PYRIDINE-2-YL CARBOXYLIC ACID AMIDES | GRM2, GRM1, GRM3 | NT5E 2347/4885KDM4E 1168/4885TAS2R14 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.