Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | FASN | P49327 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TET3 | O43151 | 1/20 | 0.57 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.57 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.57 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.57 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104296 | 0.92 | CA12 (0.58) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3092755 | 0.92 | KMT2A (0.59) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3095501 | 0.92 | CA12 (0.55) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3107076 | 0.89 | CA12 (0.53) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3110051 | 0.89 | MKNK1 (0.61) | MAPK1HPGDFASNCA12CA1 | |
| SCHEMBL8162122 | 0.89 | CA12 (0.71) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3104354 | 0.88 | SLC6A7 (0.54) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3109935 | 0.88 | ALDH1A1 (0.50) | MAPK1HPGDFASNPOLBKMT2A | |
| SCHEMBL3104333 | 0.88 | ALDH1A1 (0.52) | MAPK1HPGDFASNKMT2ATET3 | |
| SCHEMBL3091648 | 0.87 | TACR2 (0.50) | MAPK1HPGDFASNPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HTR3A, OPRL1, OPRK1 | MAPK1 2085/4885HPGD 1256/4885FASN 3975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.