Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31017633 | 0.84 | BRD4 (0.42) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL30022454 | 0.80 | CHRM2 (0.59) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL13696680 | 0.80 | CHRM2 (0.59) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL29773883 | 0.80 | CHRM2 (0.49) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL19806740 | 0.79 | DDB1 (0.42) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL27905863 | 0.77 | CHRM2 (0.49) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL20581055 | 0.76 | TLR9 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL20580961 | 0.76 | TLR9 (0.47) | KDM4EALDH1A1 | |
| SCHEMBL27962863 | 0.72 | GABRG2 (0.61) | CHRM2CHRM4CHRM1CHRM3GABRG2 | |
| SCHEMBL27905858 | 0.72 | GBA1 (0.44) | CHRM2CHRM4CHRM1CHRM3GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118414336-A | Degradation of Bruton Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2024-07-30 | — | — | CN | disclosed |