Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | FADS1 | O60427 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13641231 | 1.00 | MAPT (0.63) | MAPTGAAATMPOLBFADS1 | |
| Metaquine SCHEMBL7205743 | 0.85 | FADS1 (0.71) | MAPTGAAATMPOLBFADS1 | |
| SCHEMBL5309628 | 0.85 | MAPT (0.74) | MAPTGAAATMPOLBFADS1 | |
| SCHEMBL21346893 | 0.82 | MAPT (0.74) | MAPTGAAATMFADS1GAK | |
| SCHEMBL19633680 | 0.80 | FADS1 (0.63) | MAPTGAAATMPOLBFADS1 | |
| SCHEMBL30179800 | 0.80 | GAA (0.73) | MAPTGAAATMPOLBFADS1 | |
| SCHEMBL2011565 | 0.80 | GAA (0.73) | MAPTGAAATMPOLBFADS1 | |
| SCHEMBL22163535 | 0.77 | PKM (0.76) | MAPTPOLBCYP1A2CCR1PKM | |
| SCHEMBL2012878 | 0.77 | MAPT (1.00) | MAPTGAAATMGAKKMT2A | |
| SCHEMBL15972583 | 0.77 | MAPT (0.66) | MAPTGAAATMFADS1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3866802-B1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | UNIV DUKE (US) | 2024-08-21 | — | — | EP | claimed |
| CN-112867711-B | Quinone reductase 2 inhibitor compounds and uses thereof | 杜克大学 | 2025-02-18 | — | — | CN | disclosed |
| CN-112823006-B | Quinone reductase 2 inhibitors as neuroprotective agents | 杜克大学 | 2024-09-17 | — | — | CN | disclosed |