SCHEMBL31024668

SCHEMBL31024668

COC(=O)c1cc2c(cc1C)OC1(CO2)CN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EED O75530 1/20 0.36
▸ RBBP4 Q09028 1/20 0.36
▸ SUZ12 Q15022 1/20 0.36
▸ EZH2 Q15910 1/20 0.36
▸ AEBP2 Q6ZN18 1/20 0.36
▸ GPR183 P32249 1/20 0.36
▸ PKM P14618 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ NR1H2 P55055 1/20 0.35
▸ LMNA P02545 1/20 0.33
▸ GPR119 Q8TDV5 3/20 0.33
▸ IDO1 P14902 1/20 0.33
▸ EHMT2 Q96KQ7 1/20 0.33
▸ MEN1 O00255 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ ACACB O00763 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ MKNK1 Q9BUB5 1/20 0.32
▸ HRH3 Q9Y5N1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31024662 1.00 EED (0.36) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL25345030 1.00 EED (0.36) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31024681 0.90 PKM (0.42) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31024719 0.90 PKM (0.42) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31024669 0.85 GPR119 (0.40) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31024717 0.83 GPR119 (0.43) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL25341643 0.81 HDAC3 (0.44) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31738777 0.81 IDO1 (0.37) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31738755 0.81 IDO1 (0.37) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL30746323 0.78 GPR119 (0.38) GPR183ALDH1A1KDM4EGPR119IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656642-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF GAN & LEE PHARM CO., LTD (CN) 2025-12-03 — — EP disclosed
WO-2025026283-A1 COMPOUND FOR SELECTIVELY DEGRADING SMARCA2/4 AND USE THEREOF 甘李药业股份有限公司 2025-02-06 — — WO disclosed
WO-2024156294-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF 甘李药业股份有限公司 2024-08-02 — — WO disclosed
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