Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891648 | 0.86 | — | — | |
| Bicarbonate SCHEMBL28136957 | 0.73 | CA2 (0.50) | THRBCA1CA2CA9TET2 | |
| Bicarbonate SCHEMBL28656357 | 0.73 | CA2 (0.50) | THRBCA1CA2CA9TET2 | |
| Biphenyl SCHEMBL27620162 | 0.71 | KIF11 (0.48) | CA1CA2PDK2ALDH1A1TSHR | |
| Bicarbonate SCHEMBL28340679 | 0.69 | — | — | |
| SCHEMBL8615329 | 0.69 | — | — | |
| SCHEMBL25616 | 0.69 | — | — | |
| Bicarbonate SCHEMBL29165355 | 0.67 | — | — | |
| SCHEMBL31548817 | 0.65 | — | — | |
| SCHEMBL8618195 | 0.65 | THRB (0.30) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118440043-A | Synthesis method of fluorine-containing cyclic ether olefin | 上海氟嘉新材料科技有限公司 | 2024-08-06 | — | — | CN | disclosed |