SCHEMBL31025931

SCHEMBL31025931

O=C(O)c1[nH]c2cc(Cl)ccc2c1CN1CCOCC1

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 1/20 0.57
HSD17B10 Q99714 2/20 0.52
KDM4E B2RXH2 1/20 0.52
GAA P10253 1/20 0.52
MAPT P10636 1/20 0.52
ALOX15 P16050 1/20 0.52
MCL1 Q07820 2/20 0.50
BCL2 P10415 1/20 0.50
HTT P42858 1/20 0.49
MDM2 Q00987 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18886833 0.83 HSD17B10 (0.70) HSD17B10KDM4EGAAMAPTALOX15
SCHEMBL31025920 0.83 HSD17B10 (0.70) HSD17B10KDM4EGAAMAPTALOX15
SCHEMBL27344320 0.81 MCL1 (0.49) HSD17B10KDM4EGAAMAPTALOX15
SCHEMBL31025926 0.76 GPR17 (0.72) GPR17MCL1BCL2
SCHEMBL9187231 0.75 GPR17 (0.74) GPR17
SCHEMBL9449473 0.74 GPR17 (0.77) GPR17MCL1BCL2
SCHEMBL9449366 0.73 GPR17 (0.71) GPR17MCL1BCL2
SCHEMBL3239036 0.73 GPR17 (1.00) GPR17KDM4E
SCHEMBL8910112 0.73 GPR17 (0.61) GPR17KDM4E
SCHEMBL27344324 0.73 KDM4E (0.56) HSD17B10KDM4EGAAMAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4660193-A1 INDOLE COMPOUND DECOMPOSING IKZF2, AND USE THEREOF Korea Research Institute of Chemical Technology (KR) 2025-12-10 EP disclosed
WO-2024162746-A1 INDOLE COMPOUND DECOMPOSING IKZF2, AND USE THEREOF 한국화학연구원 2024-08-08 WO disclosed