Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.59 |
| ▸ | RXRB | P28702 | 2/20 | 0.59 |
| ▸ | RXRG | P48443 | 2/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31032329 | 0.85 | RXRA (0.57) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL9840655 | 0.81 | L3MBTL1 (0.49) | — | |
| SCHEMBL4723962 | 0.81 | RXRA (0.57) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL2527329 | 0.80 | HTR2C (0.54) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL4720380 | 0.79 | RXRA (0.65) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL1462035 | 0.79 | HTR1A (0.57) | RXRARXRB | |
| SCHEMBL31757878 | 0.79 | HTR1A (0.57) | RXRARXRB | |
| SCHEMBL28544263 | 0.79 | RXRA (0.60) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL538233 | 0.76 | RXRA (0.57) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL31406760 | 0.76 | RXRA (0.58) | RXRARXRBRXRGMRGPRX4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658640-A1 | PYRIDIN-2(1H)-ONES AND PYRIMIDIN-4(3H)-ONES AS NLRP3 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160693-A1 | PYRIDIN-2(1H)-ONES AND PYRIMIDIN-4(3H)-ONES AS NLRP3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-08-08 | — | — | WO | disclosed |