Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397878 | 0.97 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL123421 | 0.97 | CRHR1 (1.00) | CRHR1 | |
| Hydrochloric Acid SCHEMBL3103253 | 0.96 | CRHR1 (0.97) | CRHR1 | |
| SCHEMBL5844686 | 0.90 | CRHR1 (0.86) | CRHR1 | |
| SCHEMBL6805038 | 0.88 | CRHR1 (0.82) | CRHR1 | |
| SCHEMBL5842552 | 0.87 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL5600147 | 0.87 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL5845329 | 0.87 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL5844051 | 0.87 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL5845027 | 0.86 | CRHR1 (0.79) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883209-B2 | Pharmaceutical solid dispersions | BEND RESEARCH, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8828442-B2 | Pharmaceutical solid dispersions | BEND RESEARCH, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8481081-B2 | Pharmaceutical solid dispersions | BEND RESEARCH, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20130029965-A1 | PHARMACEUTICAL SOLID DISPERSIONS | BEND RESEARCH, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-20100256110-A1 | PHARMACEUTICAL SOLID DISPERSIONS | PFIZER PRODUCTS INC. | 2010-10-07 | — | — | US | disclosed |
| EP-1027886-B1 | Pharmaceutical solid dispersions | PFIZER PROD INC (US) | 2008-07-09 | — | — | EP | disclosed |
| US-20040013734-A1 | Mixture of water insoluble drug and polymer | PFIZER INC. | 2004-01-22 | — | — | US | disclosed |
| EP-1027886-A2 | Pharmaceutical solid dispersions | Pfizer Products Inc. (US) | 2000-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040013734-A1 | Mixture of water insoluble drug and polymer | ABCG2, ABCB1, ABCB11 | CRHR1 3733/4885 |
| US-20100256110-A1 | PHARMACEUTICAL SOLID DISPERSIONS | ABCG2, ABCB11, CYP2C19 | CRHR1 3253/4885 |
| US-20130029965-A1 | PHARMACEUTICAL SOLID DISPERSIONS | ABCG2, GRAMD1A, CYP2C19 | CRHR1 3881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.