SCHEMBL310345

SCHEMBL310345

C[Si](C)(C)c1cccc(C=O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
BRD4 O60885 1/20 0.45
UNG P13051 1/20 0.44
SRC P12931 1/20 0.43
CYP2A6 P11509 1/20 0.42
ACHE P22303 1/20 0.42
CDK8 P49336 1/20 0.38
TRIM24 O15164 1/20 0.38
TRIM33 Q9UPN9 1/20 0.38
MAOA P21397 3/20 0.38
MAOB P27338 3/20 0.38
AOX1 Q06278 1/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
RAB9A P51151 2/20 0.37
FGFR1 P11362 1/20 0.37
NPC1 O15118 1/20 0.37
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20590779 0.83 UNG (0.46) ALDH1A1BRD4UNGSRCCYP2A6
SCHEMBL8734121 0.82 NFE2L2 (0.44) ACHEMAOAMAOBNPC1PTGS2
SCHEMBL8734119 0.82 NFE2L2 (0.44) ACHEMAOAMAOBNPC1PTGS2
SCHEMBL7634021 0.80 BRD4 (0.47) ALDH1A1BRD4UNGSRCCYP2A6
SCHEMBL7628213 0.80 BRD4 (0.44) ALDH1A1BRD4UNGSRCCYP2A6
SCHEMBL3157051 0.78 TP53 (0.54) ALDH1A1BRD4ACHETDP1TSHR
SCHEMBL9116838 0.78 ACHE (0.42) ACHETDP1
SCHEMBL8733085 0.77 NFE2L2 (0.50) ALDH1A1MAOAMAOBRAB9ANPC1
SCHEMBL8766999 0.77 ACHE (0.37) ALDH1A1CYP2A6ACHEMAOAMAOB
SCHEMBL8733083 0.77 NFE2L2 (0.50) ALDH1A1MAOAMAOBRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US claimed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP claimed
EP-4448618-B1 METHOD FOR SEQUESTERING METHIONINE CONTAINED IN A LIQUID AND MATERIAL SUITABLE FOR IMPLEMENTING SUCH A METHOD UNIV BORDEAUX (FR) 2025-10-29 EP disclosed
EP-4448618-A1 METHOD FOR SEQUESTERING METHIONINE CONTAINED IN A LIQUID AND MATERIAL SUITABLE FOR IMPLEMENTING SUCH A METHOD Université de Bordeaux (FR) 2024-10-23 EP disclosed
WO-2023110915-A1 METHOD FOR SEQUESTERING METHIONINE CONTAINED IN A LIQUID AND MATERIAL SUITABLE FOR IMPLEMENTING SUCH A METHOD Universite de Bordeaux (FR) 2023-06-22 WO disclosed
EP-2235015-B1 AZABICYCLIC CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2016-08-24 EP disclosed
CN-102143956-B Derivatives of indole-2-carboxamides and azaindole-2-carboxamides substituted by silane groups, preparation thereof and therapeutic use thereof SANOFI AVENTIS 2014-04-23 CN disclosed
US-8604050-B2 Bicyclic derivatives of azabicyclic carboxamides, preparation thereof and therapeutic use thereof SANOFI (FR) 2013-12-10 US disclosed
EP-2235014-B1 BICYCLIC DERIVATIVES OF AZABICYCLIC CARBOXAMIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2013-10-09 EP disclosed
US-8399491-B2 Derivatives of indole-2-carboxamides and of azaindole-2-carboxamides substituted with a silanyl group, preparation thereof and therapeutic use thereof SANOFI (FR) 2013-03-19 US disclosed
US-8354425-B2 Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2013-01-15 US disclosed
EP-1233014-A1 ASYMMETRIC ORGANIC PEROXIDE, CROSSLINKING AGENT COMPRISING THE SAME, AND METHOD OF CROSSLINKING WITH THE SAME NOF CORPORATION (JP) 2002-08-21 EP disclosed
US-5693668-A SILYLATED AROMATIC FLUOROKETONES; ALZHEIMER'S DISEASE; SENILE DEMENTIA; MYATHENIA GRAVIS; MUSCULAR DYSTROPHY; GLAUCOMA; TRANSDERMAL PATCHES MERRELL PHARMACEUTICALS INC. (US) 1997-12-02 US disclosed
EP-0409676-B1 Novel acetylcholinesterase inhibitors MERRELL DOW PHARMA (US) 1995-03-08 EP disclosed
CN-1027759-C Novel acetylcholinesterase inhibitors MERRELL DOW PHARMA (US) 1995-03-01 CN disclosed
EP-0409676-A1 Novel acetylcholinesterase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1991-01-23 EP disclosed
CN-1048389-A New acetylcholinesterase depressant MERRELL DOW PHARMA (US) 1991-01-09 CN disclosed
EP-0403713-A1 Novel acetylcholinesterase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1990-12-27 EP disclosed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US disclosed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP disclosed