Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.51 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31274032 | 0.88 | CRBN (0.53) | CRBNEPHX2PARP1 | |
| SCHEMBL20411482 | 0.83 | MGLL (0.65) | ACACBSCD5MGLLCYP11B2TNKS | |
| SCHEMBL29614918 | 0.80 | ANO1 (0.55) | EPHX2HDAC2HDAC1 | |
| SCHEMBL22031492 | 0.80 | ANO1 (0.55) | EPHX2HDAC2HDAC1 | |
| SCHEMBL14742358 | 0.78 | SCD5 (0.64) | ACACBSCD5MGLLCYP11B2TNKS | |
| Trifluoroacetic Acid SCHEMBL29614978 | 0.78 | GABRD (0.52) | MGLLCYP2C9CYP2C19MAPK1 | |
| SCHEMBL222011 | 0.76 | GPR119 (0.53) | MGLLCRBNEPHX2PARP1 | |
| SCHEMBL5428425 | 0.75 | MEN1 (0.56) | SCD5MGLLCYP2C9CYP2C19MAPK1 | |
| SCHEMBL20183894 | 0.75 | CRBN (0.49) | ACACBCRBNEPHX2MAPK1 | |
| SCHEMBL22031528 | 0.74 | USP30 (0.55) | EPHX2PARP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285873-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-111285874-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |