Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11031904 | 0.87 | ALDH1A1 (0.59) | ALDH1A1HSD17B10KDM4ESMN1; SMN2MAPT | |
| SCHEMBL11202923 | 0.81 | KMT2A (0.49) | ALDH1A1HSD17B10KDM4EHTTCA12 | |
| SCHEMBL9442187 | 0.81 | ALDH1A1 (0.68) | ALDH1A1HSD17B10KDM4ESMN1; SMN2GAA | |
| SCHEMBL2187600 | 0.78 | ALPL (0.49) | ALDH1A1ALPLALPIALPGSMN1; SMN2 | |
| SCHEMBL2795240 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EALPLALPIALPG | |
| SCHEMBL3949534 | 0.77 | ALDH1A1 (0.51) | ALDH1A1ALPLALPIALPGSMN1; SMN2 | |
| SCHEMBL4633649 | 0.75 | ALPL (0.47) | ALDH1A1ALPLALPIALPGSMN1; SMN2 | |
| SCHEMBL27136388 | 0.75 | SMN1; SMN2 (0.51) | ALDH1A1KDM4EALPLALPIALPG | |
| SCHEMBL2264097 | 0.75 | MCL1 (0.54) | ALDH1A1HSD17B10KDM4ESMN1; SMN2GAA | |
| SCHEMBL5481312 | 0.75 | ALDH1A1 (0.60) | ALDH1A1HSD17B10KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024194607-A1 | PYRIMIDO[4,5-B][1,5]NAPHTHYRIDINE-4,5(3H,10H)-DIONE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PTC MUTATIONS, SUCH AS E.G. CANCER | Tay Therapeutics Limited (GB) | 2024-09-26 | — | — | WO | disclosed |