Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PDE8B | O95263 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20399730 | 1.00 | POLB (0.50) | POLBL3MBTL1PDE8BHPGDEPHX1 | |
| SCHEMBL31323435 | 1.00 | POLB (0.50) | POLBL3MBTL1PDE8BHPGDEPHX1 | |
| SCHEMBL192841 | 0.98 | POLB (0.51) | POLBL3MBTL1PDE8BHPGDEPHX1 | |
| SCHEMBL282976 | 0.98 | POLB (0.51) | POLBL3MBTL1PDE8BHPGDEPHX1 | |
| SCHEMBL282977 | 0.98 | POLB (0.51) | POLBL3MBTL1PDE8BHPGDEPHX1 | |
| SCHEMBL135177 | 0.94 | L3MBTL1 (0.58) | POLBL3MBTL1PDE8BHPGDATM | |
| SCHEMBL47049 | 0.94 | L3MBTL1 (0.58) | POLBL3MBTL1PDE8BHPGDATM | |
| SCHEMBL133363 | 0.94 | L3MBTL1 (0.58) | POLBL3MBTL1PDE8BHPGDATM | |
| SCHEMBL3769601 | 0.90 | HPGD (0.54) | POLBL3MBTL1PDE8BHPGDEPHX1 | |
| SCHEMBL3769598 | 0.90 | HPGD (0.54) | POLBL3MBTL1PDE8BHPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735438-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| EP-4695260-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2026-02-18 | — | — | EP | disclosed |
| WO-2025006783-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |
| US-20240383922-A1 | KRAS Modulating Compounds | GILEAD SCIENCES, INC. | 2024-11-21 | — | — | US | disclosed |
| WO-2024215754-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2024-10-17 | — | — | WO | disclosed |
| WO-2024178304-A1 | KRAS MODULATORS | ALTEROME THERAPEUTICS, INC. (US) | 2024-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240383922-A1 | KRAS Modulating Compounds | KRAS, NRAS, HRAS | POLB 1907/4885L3MBTL1 2862/4885PDE8B 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.