Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670816 | 0.87 | CES2 (0.41) | CES2CES1HDAC1HDAC6ALOX15 | |
| SCHEMBL9524677 | 0.85 | TTR (0.39) | TTRALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL31174965 | 0.84 | TTR (0.52) | TTRALDH1A1TSHRRAB9APLAU | |
| SCHEMBL31049112 | 0.84 | TTR (0.52) | TTRALDH1A1TSHRRAB9APLAU | |
| SCHEMBL17041582 | 0.82 | CA5A (0.39) | CES2CES1HDAC1HDAC6TTR | |
| SCHEMBL31048985 | 0.81 | HDAC6 (0.56) | HDAC1HDAC6ALOX15 | |
| SCHEMBL7922027 | 0.79 | CES2 (0.48) | CES2CES1HDAC1HDAC6TTR | |
| SCHEMBL31701851 | 0.78 | HDAC1 (0.41) | CES2CES1HDAC1HDAC6KCNQ3 | |
| SCHEMBL31049141 | 0.78 | KDM4E (0.47) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7922005 | 0.76 | CES2 (0.42) | CES2CES1HDAC1HDAC6TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024167922-A2 | HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-08-15 | — | — | WO | disclosed |