Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049388 | 0.90 | MEN1 (0.33) | JAK2JAK3HPGDALDH1A1 | |
| SCHEMBL31049371 | 0.83 | ALDH1A1 (0.34) | RENHPGDALDH1A1 | |
| SCHEMBL31049269 | 0.83 | ALDH1A1 (0.35) | HPGDFEN1ALDH1A1 | |
| SCHEMBL31049293 | 0.81 | ALDH1A1 (0.34) | JAK2JAK3HPGDALDH1A1 | |
| SCHEMBL31049311 | 0.77 | CNR2 (0.37) | JAK2JAK3HPGDMAPK1KDM1A | |
| SCHEMBL3792320 | 0.70 | ALDH1A1 (0.39) | JAK2JAK3HPGDMAPK1ALDH1A1 | |
| SCHEMBL31049356 | 0.68 | CNR2 (0.47) | JAK3HPGDALDH1A1 | |
| SCHEMBL31049408 | 0.67 | IP6K1 (0.32) | — | |
| SCHEMBL1139688 | 0.65 | ALDH1A1 (0.41) | HPGDMAPK1FEN1ALDH1A1 | |
| SCHEMBL27077566 | 0.63 | ALDH1A1 (0.37) | HPGDMAPK1FEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |