Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049273 | 0.90 | REN (0.33) | ALDH1A1HPGDJAK2JAK3 | |
| SCHEMBL31049371 | 0.86 | ALDH1A1 (0.34) | POLBMAPTHDAC1HDAC6ALDH1A1 | |
| SCHEMBL31049269 | 0.86 | ALDH1A1 (0.35) | ALDH1A1HPGDGAAHTT | |
| SCHEMBL31049293 | 0.84 | ALDH1A1 (0.34) | HDAC1HDAC6ALDH1A1HDAC3HDAC7 | |
| SCHEMBL31049356 | 0.74 | CNR2 (0.47) | MEN1KMT2AKDM4EHDAC1HDAC6 | |
| SCHEMBL31049408 | 0.70 | IP6K1 (0.32) | — | |
| SCHEMBL31049311 | 0.67 | CNR2 (0.37) | KMT2APOLBMAPTLMNAALDH1A1 | |
| SCHEMBL3792320 | 0.65 | ALDH1A1 (0.39) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL31049393 | 0.64 | ICMT (0.41) | KMT2AMAPTLMNAALDH1A1HPGD | |
| SCHEMBL31049268 | 0.64 | ALDH1A1 (0.36) | KMT2APOLBLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |