Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049343 | 0.85 | GRIN2B (0.32) | GRIN2BICMTKCNA3KCNA5KDM4E | |
| SCHEMBL31049353 | 0.71 | KDM4E (0.33) | GRIN2BPOLBHTTTLR8TLR7 | |
| SCHEMBL31049261 | 0.70 | KDM4E (0.37) | GRIN2BPOLBKMT2AMEN1ICMT | |
| SCHEMBL7100687 | 0.67 | DAO (0.43) | HTTTLR8TLR7KCNA3KCNA5 | |
| SCHEMBL45207 | 0.64 | TLR8 (0.44) | POLBKMT2AHTTTLR8TLR7 | |
| SCHEMBL6114640 | 0.63 | TBXAS1 (0.47) | POLBHTTTLR8TLR7KDM4E | |
| SCHEMBL6114927 | 0.63 | TBXAS1 (0.47) | POLBHTTTLR8TLR7KDM4E | |
| SCHEMBL11440961 | 0.63 | TBXAS1 (0.47) | POLBHTTTLR8TLR7KDM4E | |
| SCHEMBL11438392 | 0.63 | TBXAS1 (0.47) | POLBHTTTLR8TLR7KDM4E | |
| SCHEMBL6114716 | 0.63 | TBXAS1 (0.47) | POLBHTTTLR8TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |