Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 2/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31052848 | 0.95 | ITGB1 (0.54) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL31052774 | 0.80 | EGFR (0.44) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL29416420 | 0.80 | ALDH1A1 (0.64) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL1516426 | 0.80 | ALDH1A1 (0.64) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL30587068 | 0.80 | ALDH1A1 (0.64) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL31052849 | 0.79 | ALDH1A1 (0.52) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL31052788 | 0.79 | RPS6KB1 (0.43) | ALDH1A1NPSR1PRNPTSHRMAPK10 | |
| SCHEMBL14285630 | 0.78 | ITGB1 (0.53) | ITGB1ITGA4ALDH1A1NPSR1PRNP | |
| SCHEMBL31052926 | 0.77 | GRN (0.44) | ITGB1ITGA4ALDH1A1TSHRITGAV | |
| SCHEMBL31052883 | 0.77 | GRN (0.44) | ITGB1ITGA4ALDH1A1TSHRITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676914-A1 | MODULATORS OF SORTILIN ACTIVITY | Vesper Bio Aps (DK) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024184469-A1 | MODULATORS OF SORTILIN ACTIVITY | VESPER BIO APS (DK) | 2024-09-12 | — | — | WO | disclosed |
| EP-4428121-A1 | MODULATORS OF SORTILIN ACTIVITY | Vesper Bio Aps (DK) | 2024-09-11 | — | — | EP | disclosed |