Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903845 | 0.86 | MAPT (0.34) | ALDH1A1NPC1POLBRAB9A | |
| SCHEMBL11920886 | 0.84 | ATR (0.36) | ALDH1A1GAA | |
| SCHEMBL11904388 | 0.77 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL3107545 | 0.74 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL3103128 | 0.74 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL3116095 | 0.72 | CRHR1 (0.33) | CRHR1ALDH1A1NPC1RAB9A | |
| SCHEMBL13671446 | 0.71 | ATR (0.36) | ALDH1A1GAA | |
| SCHEMBL11920890 | 0.63 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL11904180 | 0.61 | MAPT (0.32) | ALDH1A1NPC1POLBRAB9A | |
| SCHEMBL11903992 | 0.58 | LMNA (0.34) | ALDH1A1NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431603-B2 | 3-phenylpyrazolo[5,1-b]thiazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-30 | — | — | US | disclosed |
| EP-2266990-B1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-26 | — | — | EP | disclosed |
| EP-2487178-A1 | PYRAZOLOTHIAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |
| EP-2266990-A1 | 3-PHENYLPYRAZOLOÝ5,1-b¨THIAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-20090259049-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090259049-A1 | 3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUNDS | CRHR1, AGTR1, CRHR2 | CRHR1 1/4885ALDH1A1 1071/4885NPC1 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.