Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23175129 | 0.90 | LMNA (0.70) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL28605800 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL30281263 | 0.76 | ALDH1A1 (0.57) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL28647100 | 0.75 | ALDH1A1 (0.53) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL34461806 | 0.75 | ALDH1A1 (0.65) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL30366498 | 0.75 | ALDH1A1 (0.65) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL13730424 | 0.75 | LTA4H (0.48) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL854692 | 0.74 | NPSR1 (0.70) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL28391873 | 0.73 | ALDH1A1 (0.54) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL28039277 | 0.73 | ALDH1A1 (0.50) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362241-B2 | Inhibitors of PI3 kinase and/or mTOR | AMGEN INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | AMGEN INC. (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273764-A1 | INHIBITORS OF PI3 KINASE AND/OR MTOR | MTOR, PIK3CA, PIK3CD | ALDH1A1 4256/4885CYP2D6 3926/4885ATM 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.