Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22163218 | 1.00 | PIM1 (0.44) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22471258 | 0.85 | GRIN2B (0.46) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30464684 | 0.85 | GRIN2B (0.46) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22163226 | 0.81 | KIF18A (0.44) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31066073 | 0.81 | KIF18A (0.44) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14890189 | 0.79 | GRIN2D (0.48) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18278380 | 0.76 | FFAR2 (0.43) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL465738 | 0.76 | GRIN2D (0.57) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1809857 | 0.76 | GRIN2D (0.57) | PIM1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14890661 | 0.75 | GRIN2D (0.50) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441736-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2025-10-14 | — | — | US | disclosed |
| EP-3898592-B1 | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | AMGEN INC (US) | 2024-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12441736-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | PIM1 3477/4885GRIN2D 4395/4885GRIN3B 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.