Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 20/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.66 |
| ▸ | TSHR | P16473 | 11/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.57 |
| ▸ | CASP1 | P29466 | 5/20 | 0.57 |
| ▸ | CASP7 | P55210 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068655 | 0.78 | PDE10A (0.48) | CYP1A2ALDH1A1TSHRCLK4 | |
| SCHEMBL8674551 | 0.74 | CDK1 (0.59) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL24394711 | 0.73 | CYP1A2 (0.44) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL30545109 | 0.73 | CYP1A2 (0.44) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL31068640 | 0.71 | GABRP (0.44) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL10615795 | 0.70 | STAT3 (0.51) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL26971403 | 0.69 | CYP1A2 (0.57) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL11009131 | 0.68 | TSHR (0.52) | CYP1A2TSHRCYP2C19CYP3A4LMNA | |
| SCHEMBL5440110 | 0.68 | CYP1A2 (0.48) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 | |
| SCHEMBL21514306 | 0.68 | CYP1A2 (0.52) | CYP1A2ALDH1A1TSHRCLK4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240254114-A1 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240254114-A1 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS | DGAT2, DGAT1, ACAT2 | CYP1A2 126/4885ALDH1A1 984/4885TSHR 4284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.